I picked the life threatening disease thingy. 10% of anything I win gets split between Childrens hospitals in Nashville and Birmingham and St. Judes in Memphis.
The rest I spend making my friends and family happy and providing them with financial security while throwing some back for the grandkids.
I would use some of the money to help family, and friends who may need an extra helping hand, wisely invest a percentage to live on in the future, and give the remainder to various charities, and helpful organisations.