Antidepressants Under Scrutiny Over Efficacy

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gLing

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The effectiveness of a dozen popular antidepressants has been exaggerated by selective publication of favorable results, according to a review of unpublished data submitted to the Food and Drug Administration.

As a result, doctors and patients are getting a distorted view of how well blockbuster antidepressants like Wyeth's Effexor and Pfizer Inc.'s Zoloft really work, researchers asserted in this week's New England Journal of Medicine.

Since the overwhelming amount of published data on the drugs show they are effective, doctors unaware of the unpublished data are making inappropriate prescribing decisions that aren't in the best interest of their patients, according to researchers led by Erick Turner, a psychiatrist at Oregon Health & Science University. Sales of antidepressants total about $21 billion a year, according to IMS Health
Antidepressants Under Scrutiny Over Efficacy - WSJ.com
 
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Breath

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I've seen antidepressants work miracles in some people's lives. I believe the discrepancy arises in that not all of them "work" in all people. There is such a range in effectiveness from person to person. If one doesn't work, the next one might. That's why it's immensely important to keep in contact with your physician and to return for follow-up appointments.
 

redsMULLT1

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Well all I know first hand is that my missus is on Effexor and she's an absolute nightmare if she forgets to take it.


Oh my... I tried effexor for a bit... I was nothing short of a train wreck on that stuff. Even worse when I got off it. Everythings cool now though.
 

Ria

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This has been discussed in documentaries and the news numerous times.

Also, depending on the manufacturer, the same medication (I believe in others besides anti-depressants too), has different names also, which causes complications and confusion for the patients.

There have also been documentaries showing illegal drugs factories (making fake medications and selling through a middle man (a dodgy drugs company) to hospitals, chemists, all over - these drugs factories were shown in the programmes. The supposed meds they make fake, do not have the necessary ingredients required for those meds - as long as they appear to be the same, then they will get their money. They also add things that will make them harmful.

These are the kind of things that have actually been shown on TV - haven't seen a documentary recently, but it takes a lot of recourses to bust those fake meds factories, so they are still getting away with it, causing potential and actual harm to people in need of those very meds.

That is sick imo. :mad
 

gLing

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In my opinion I think society is way over medicated. If you are feeling down because you are not part of the "in" crowd at school well then just take some pills and feel all better!
Your child acting up in class? Well he must have ADD so lets pump him full of pharmaceuticals. etc. etc.
 

debbie t

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if society is over medicated its because were now lucky enough to have the necessary medication available for illnesses such as depression.depression isnt just feeling low ,its debilitating both physically and mentally,and is a life threatening illness.
i would imagine that not all pharmaceuticals react with all people and so its a case of finding the correct medication and most effective dose for that person.
 

gLing

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if society is over medicated its because were now lucky enough to have the necessary medication available for illnesses such as depression.depression isnt just feeling low ,its debilitating both physically and mentally,and is a life threatening illness.
i would imagine that not all pharmaceuticals react with all people and so its a case of finding the correct medication and most effective dose for that person.
But I'm not talking about real depression, the kind that shuts your life down. I'm talking about how doctors are quick to hand out medication if you happen to mention you've been feeling low lately.
My doctor did that to me once. During a checkup last year as one of the questions she asked how I was feeling lately. I told her I was a little down but didn't know why. So she gives me a prescription of zoloft.
 

debbie t

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do you have to pay for medication in america or is it funded by the state?,if you are paying lots then the drug companies often push medication to make profit.
 

gLing

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do you have to pay for medication in america or is it funded by the state?,if you are paying lots then the drug companies often push medication to make profit.
It's paid for mostly by the insurance and I only pay about $10. The drug companies do push medication a lot because they can bilk the insurance companies that way. When you to the doctor they will even hand out samples of medication for you to take home like candy.
 

gLing

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samples???..only in america:unsure:
Yes! Doctors get boxes of samples from pharmaceuticals companies to pass out to their patients. My doctor used to give me samples of ambien to help with my insomnia. After I tried them I decided to fill my prescription. lol
 

Ria

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But I'm not talking about real depression, the kind that shuts your life down. I'm talking about how doctors are quick to hand out medication if you happen to mention you've been feeling low lately.
My doctor did that to me once. During a checkup last year as one of the questions she asked how I was feeling lately. I told her I was a little down but didn't know why. So she gives me a prescription of zoloft.

A patient is always able to reject meds though and my docs have also suggested meds for other things for instance, but i have been able to refuse if i haven't been happy or sure about it.

It's the illegal backstreet type, false drugs factories that have a lot to answer for thought, according to what i have watched a few times on documentaries. Hospitals and Chemists are not in the know and buy the drugs on trust.

Tricky one there - food for thought. :(
 

gLing

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Oh yes you can refuse. In my case I simply do not fill the prescription.
I don't know about the backstreet drug factories, I wouldn't be surprised about though considering how expensive pharmaceuticals are.
 

Ria

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Oh yes you can refuse. In my case I simply do not fill the prescription.
I don't know about the backstreet drug factories, I wouldn't be surprised about though considering how expensive pharmaceuticals are.

Yeah, best way, not to fill out prescription certificates if not wanted. ;)

The backstreets, via a middle man, actually sell their fakes though to hospitals and chemists for anywhere to use, any town, city etc - they're not doing it for their own personal usage. :(

Anyone can end up with fake meds and no-one's to know until a tragedy happens. :mad
 

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First, we know these medications work. There is no doubt that they are effective. The question is How effective.

Second, in the US, insurance companies encourage primary care physicians to make treatment decisions, rather than allowing patients to go to a psychiatrist, who most likely is aware of the unpublished studies. Primary care physicians basically have default medications for different complaints, for a variety of reasons.

Third, drug samples play an important role in the US, as it allows a doctor to find the appropriate treatment options without incurring patient costs. Drug samples are also given to people who cannot afford the medication.

Fourth, this article seems to take the tone that patients should have all available clinical data on the medications they take, which I do not believe they should. Generally speaking, patients are incapable of interpreting data properly. The FDA should go back to forbidding drug companies from general advertising, as it serves no purpose except to get patients to DEMAND this or that, makes the patient take a clinical role.

SSRI's and SNRI's and the like have proven clinical effect at treating depression, and most clinicians know that you have to play around with the meds until you find the right one/ones for the best outcome.
 

darkcgi

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i take them and i dont think they work
but i dont really know for sure
i plan on weening off of them in about 6 months

not that i should even think it but
i read yesterday that they are coming out with a pill
that will make you release endorphines just like when you exercise
 

FreeWorkVest

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i take them and i dont think they work
but i dont really know for sure
i plan on weening off of them in about 6 months

not that i should even think it but
i read yesterday that they are coming out with a pill
that will make you release endorphines just like when you exercise



Have to discussed this with your physician? Have you tried other meds?


And as to the second part - its called heroin :D
 
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